Ukuphakama kwe-CRP ligama abantu abaninzi abadibana nalo kwiimvavanyo zempilo namhlanje kwaye luphawu olubalulekileyo lwamanqanaba okudumba emzimbeni. I-CRP, okanye i-C-Reactive Protein, yiprotheyini eveliswa sisibindi kwaye inqanaba layo egazini lisezantsi kakhulu phantsi kweemeko eziqhelekileyo. Nangona kunjalo, xa kukho naluphi na usulelo, ukulimala okanye isifo esingapheliyo emzimbeni, inqanaba le proteni likhuphuka ngokukhawuleza. Olu lwando lubonisa ukuba indlela yokuzikhusela yomzimba iyasebenza kwaye ibalulekile ekuxilongeni kwangaphambili. Uvavanyo lwe-CRP lusetyenziswa rhoqo ekuhlolweni kwezempilo eTurkey ngenxa yokuba izifo ezinxulumene nokuvuvukala ziyanda kuluntu. Umzekelo, ngokwe Ministry of Health data, izifo ezingapheliyo zokudumba zinokuqalisa malunga ne-50 yepesenti yezifo zentliziyo. Kule ngxelo yeblogi, siza kuxubusha ngokubanzi ukuba yiyiphi i-CRP ephakamileyo, izizathu zayo, iimpawu, iindlela zokuxilongwa, iindlela zonyango kunye neendlela zokuthintela. Injongo yethu kukunceda abafundi bethu balawule impilo yabo ngononophelo ngokubanika ulwazi olubanzi.Ukuba unexhala malunga nexabiso lakho le-CRP, unokufumana inkxaso yobuchwephesha ngokwenza ividiyo okanye umnxeba wobuso ngobuso kunye noogqirha abaziingcali ngeqonga le-e-Health. Eli qonga, T.R. Ivunyiwe nguMphathiswa wezeMpilo kwaye ikuvumela ukuba ulandele ngokulula iziphumo zovavanyo lwakho enkosi ye-e-Pulse integration.
Ukuphakama kwe-CRP ayisosiphumo selabhoratri nje, luphawu lwe-alam kwilizwe elingaphakathi emzimbeni wakho. Ngokwembali, iprotheyini ye-CRP yafunyanwa kwi-1930s kwaye yaqala ukusetyenziswa kuvavanyo lwezonyango ukususela kwi-1950s. Sisixhobo esiyimfuneko kumayeza anamhlanje, ngakumbi ekuvavanyeni umngcipheko wezifo zentliziyo. Amanqanaba aphezulu e-CRP angakhokelela kwiimeko ezibizwa ngokuba ngukuvuvukala okuthe cwaka, okuqhubekayo ngaphandle kweempawu. Umzekelo, kwanemiba yobomi bemihla ngemihla njengokutyeba kakhulu okanye uxinzelelo kunokonyusa i-CRP. Kweli nqaku, siza kucacisa iingcaciso zenzululwazi ngokuzixhasa ngemizekelo, ukuze abafundi bethu bawuqonde nzulu lo mbandela. Khumbula, olu lwazi lulungiselelwe iinjongo zolwazi ngokubanzi kuphela kwaye aluthathi ndawo yeengcebiso zonyango; soloko ubonana negcisa lezempilo.
Yintoni i-CRP? CRP Height Basic Concepts
CRP imele i-C-Reactive Protein kwaye iyinxalenye ebalulekileyo yamajoni omzimba. Le proteni, eveliswa ziiseli zesibindi, idla ngokuba nenqanaba legazi le-0 ukuya ku-5 mg/L. Umsebenzi oyintloko we-CRP kukuqalisa impendulo yokuvuvukala kwizinto zangaphandle ezingena emzimbeni. Ikhuthazwa yi-cytokines efana ne-Interleukin-6 kwaye inyuka ngokukhawuleza kwimeko yokusuleleka okanye umonakalo wezicubu. Ngelixa le proteni inyuka kakhulu kwintsholongwane yebhaktheriya, inokuhlala kumanqanaba aphantsi kwizifo zentsholongwane. Uvavanyo lwe-CRP olunovakalelo oluphezulu (hs-CRP), ngokungafaniyo novavanyo oluqhelekileyo, lulinganisa amanqanaba asezantsi kwaye lusetyenziselwa ukumisela umngcipheko wesifo senhliziyo.[T]_9_T] Ubume bemolekyuli ye
CRP yaziwa njengeprotein yepentameric; Iqukethe ama-subunits amahlanu kwaye isebenze iiseli zomzimba ngokuzibophelela kwi-phospholipids egazini. Lo matshini yinxalenye yempendulo yesigaba esibukhali somzimba, kwaye iiyure emva kosulelo, amanqanaba e-CRP anokonyuka ukuya kutsho kwi-1000-fold. Amaxabiso okubhekiselwa kuwo asetyenziswa kwiilabhoratri eTurkey ngokubanzi ahambelana nemigangatho yamazwe ngamazwe; Umzekelo, kwizibhedlele zase-Acıbadem, amaxabiso angaphezu kwe-10 mg/L athathwa ngokuba phezulu. Uvavanyo lwe-CRP luvandlakanywa kunye nolunye uvavanyo lwegazi (umzekelo, i-ESR - i-Erythrocyte Sedimentation Rate) kuba i-CRP itshintsha ngokukhawuleza kwaye ivelele njengommakishi othile
Ukufundisa abafundi bethu, masixoxe ngokufutshane ngembali ye-CRP: Yaqala yachongwa njengeprotheyini esebenza ngokuchasene nebhaktheriya iStreptococcus pneumoniae. Kule mihla, kubaluleke kakhulu kulawulo lwezifo ezingapheliyo. Ngokomzekelo, xa isigulane sinomkhuhlane, inqanaba le-CRP liphakama okwethutyana, kodwa kwiimeko ezingapheliyo ezifana ne-rheumatism, lihlala liphezulu ngokusisigxina. Ukuqonda lo mahluko kwenza inkqubo yokuxilonga ibe lula. Ukuba ufuna ukwazi amaxabiso akho e-CRP, unokwenza uvavanyo lwegazi ngeenkonzo zempilo zasekhaya nge-e-Health kwaye ujonge iziphumo kwi-e-Pulse. Eli qonga likhuselwe ngokwemigangatho yabucala kunye nokhuseleko (ISO/IEC 27001) ukuze idatha yakho ihlale ikhuselekile.
Yintoni i-CRP ePhakamileyo kwaye Ithetha ukuthini?
Ukuphakama kwe-CRP kuxa inqanaba le-CRP egazini lidlula amaxabiso aqhelekileyo, kwaye amaxabiso angaphezu kwe-10 mg/L awela kolu didi ngokubanzi. Oku kubonisa ukuba kukho ukudumba, usulelo okanye umonakalo wezicubu emzimbeni. I-CRP ephakanyisiweyo inokuba yinto ebukhali okanye engapheliyo; Ngelixa amaxabiso enyuka kwaye ehla ngokukhawuleza kwiindawo eziphakamileyo, ukonyuka okuqhubekayo kubonwa kwiindawo eziphakamileyo ezingapheliyo. Olu lwando lubonisa ukuba amajoni omzimba asebenza ngokugqithisileyo kwaye anokubangela umonakalo kwiindonga zenqanawa kwixesha elide.
Ngokwenzululwazi, i-CRP ephakamileyo inxulunyaniswa nenkqubo ebizwa ngokuba yi-cytokine storm yomzimba. I-Cytokines yandisa ukuvuvukala kwaye ibangele i-CRP. I-CRP ephakamileyo inokunyusa umngcipheko wokuhlaselwa yintliziyo ngeepesenti ze-2-3 ngenxa yokuba ukuvuvukala kunciphisa iinqanawa. ETurkey, ngokweenkcukacha zeZiko lezeMpilo le-Anadolu, iziganeko zezifo zentliziyo ziphezulu kwi-30 ekhulwini kubantu abane-CRP ephezulu. Le meko yaziwa ngokuba ngumbulali ongathethiyo kuba inokuqhubeka ngaphandle kweempawu.
Umzekelo, emva kwengozi yendlela, inqanaba le-CRP liyenyuka ngenxa yokwenzakala kwaye isetyenziselwa ukubeka esweni inkqubo yokuphilisa. Kwiindawo eziphakamileyo ezingapheliyo, izifo ezifana nesifo sikashukela okanye uxinzelelo lwegazi zidlala indima. Intsingiselo ye-CRP ephakamileyo ayilonani nje kuphela, kodwa yimbonakaliso yesimo sempilo yonke yomzimba. Kubalulekile ukudibana nogqirha wakho ukutolika eli xabiso; Kwiqonga le-e-Health, iingcali ziyakwazi ukuvavanya iziphumo zakho kwaye zinike uluvo lwesibini. Le nkonzo idityaniswe ne-e-Prescription kunye ne-e-Report, ngoko ke unyango lunokuqaliswa ngokukhawuleza.
Izinto ezibangela uKunyuswa kwe-CRP
Oonobangela be-CRP ephezulu bayohluka kwaye badla ngokubangelwa kukudumba. Ezona zizathu zixhaphakileyo ziquka izifo ezosulelayo. Usulelo lwebhaktheriya (inyumoniya, i-pancreatitis) inokunyusa i-CRP ukuya kuthi ga kwi-100 mg/L kuba umzimba uphendula ngokukhawuleza. Kusulelo lwentsholongwane, ukwanda kuncinci. Izifo zeRheumatic liqela lesibini ngobukhulu; Iimeko ze-autoimmune ezifana ne-rheumatoid arthritis okanye i-lupus zihlala ziphakamisa i-CRP njengoko amajoni omzimba ahlasela izicubu zawo. Ezi zifo zibangela ukudumba neentlungu kumalungu.
Umonzakalo kunye nongenelelo lotyando lukwabanga i-CRP ephakamileyo. Emva kokuhlinzwa, umzimba uvelisa ukuvuvukala ngexesha lenkqubo yokuphilisa kwaye inqanaba le-CRP liyenyuka okwethutyana. Umhlaza ngomnye unobangela obalulekileyo; Amathumba adala ukuvuvukala kwizicubu ezijikelezileyo kwaye anyuse i-CRP. Umzekelo, i-CRP ephezulu kumhlaza wekolon inokuba luphawu lokuxilongwa kwangoko. Izifo ezingapheliyo, ezifana nokutyeba, isifo seswekile kunye noxinzelelo lwegazi, zibangela ukudumba okuphantsi. Ekutyebeni, izicubu ezinamafutha zifihla i-cytokines kwaye zandisa i-CRP; Kucingwa ukuba umlinganiselo wokutyeba eTurkey usondela kuma-30 ekhulwini, le yingxaki ebalulekileyo.
Ezinye izizathu ziquka izifo zentliziyo; I-atherosclerosis idala ukuvuvukala ngokuqokelelwa kwe-plaque kwiindonga zeenqanawa. Ukutshaya, uxinzelelo kunye nokungondleki kakuhle nako konyusa i-CRP. Ngomatshini, ezi zinto zandisa i-interleukin-6 kwaye zinyanzelise isibindi ukuba sivelise i-CRP. Imeko: Ukuba isigulane siyatshaya kwaye sityebe, i-CRP yakhe inokuhlala iphezulu, inyusa umngcipheko wokuhlaselwa yintliziyo. Iinkqubo ze-e-Health zempilo zibonelela ngezicwangciso ezizezakho ukulawula ezi zizathu, zisebenza neengcali zokutya kunye neengcali zephysiotherapist.
Iimpawu ze-CRP ephezulu
Iimpawu ze-CRP eziphezulu ziyahluka ngokuxhomekeke kwisifo esisezantsi kwaye azibangelwa ngokuthe ngqo yi-CRP. Iimpawu eziqhelekileyo ziquka umkhuhlane, ukudinwa kunye ne-malaise. Ukuvuvukala kwamasondo omzimba, ngoko ke abantu abane-CRP ephezulu banokufumana isifo esingapheliyo sokukhathala. Iintlungu ezidibeneyo kunye nokudumba zixhaphakile kwizizathu ze-rheumatic; njengokuqina kwentsasa ezandleni.
Ukubetha kwentliziyo ekhawulezayo kunye nokuphefumla nzima kwenzeka ngokuphakama okunxulumene nentliziyo. Intlungu yesifuba inokuba sisilumkiso esinzulu. Ukudumba kunye nokubomvu kwenzeka ngezifo; Ngokomzekelo, inyumoniya ihamba kunye nokukhohlela kunye nomkhuhlane. Ukuqhawuka kwesikhumba okanye ubuthathaka bemisipha ziimpawu zezifo ezizimelayo. I-CRP ephezulu inokukhokelela kwiingxaki zokulala kuba ukudumba kuchaphazela amanqanaba e-cortisol.
Njengesifundo, uhlolo lwemihla ngemihla luyacetyiswa ukuqaphela iimpawu kwangethuba: umlinganiselo wobushushu, ujongo lokushukuma kwamalungu. ETurkey, ngokutsho kweQela lezeMpilo le-Nev, iingxaki zonyuka xa iimpawu ze-CRP eziphezulu zingahoywa. Ukuba ufumana ezi mpawu, ungalawula uxinzelelo lwakho ngokufumana inkxaso yezengqondo nge-e-Health, kuba uxinzelelo ludala i-CRP.
Uvavanyo loMphakamo we-CRP
Uxilongo lwe-CRP ephezulu lwenziwa ngovavanyo olulula lwegazi. Isampuli yegazi ithathwa kwaye inqanaba le-CRP lilinganiswa elabhoratri. Uvavanyo oluqhelekileyo lufumanisa ukuvuvukala okukhulu, ngelixa i-hs-CRP ihlola ingozi yentliziyo. Akukho malungiselelo aphambi kovavanyo olufunekayo, kodwa ukuzilolonga okunzulu kunokonyusa i-CRP okwethutyana.
Iziphumo zinikwe ngo-mg/L; Ngaphezulu kwe-10 mg / L ithathwa njengephezulu. Ukuxilongwa kuxhaswa ngezinye iimvavanyo: inani elipheleleyo legazi, i-x-ray okanye i-MRI. ETurkey, olu vavanyo lwenziwa rhoqo kwizibhedlele ezifana nePaki yezoNyango. I-e-Health ibonisa iziphumo ngoko nangoko nge-e-Pulse integration, iingcali zihlomle.
Unyango kunye noLawulo lwe-CRP ePhakamileyo
Unyango lujolise koyena nobangela. Ii-antibiotics zisetyenziselwa usulelo; iziyobisi ezichasayo kwi-rheumatism. I-Aspirin inconywa kwingozi yentliziyo. Utshintsho kwindlela yokuphila lubalulekile: Ukutya okunesondlo, ukuzilolonga.
Imizekelo yeziyobisi: Ii-NSAID zinciphisa intlungu. Iimvavanyo ezilandelayo ziyenziwa. I-e-Health ithumela amayeza ekhemesti nge-e-Prescription.
Iindlela zokuNqanda i-CRP ephezulu
Uthintelo luqala kubomi obunempilo. Ukutya kweMeditera, i-omega-3s ephantsi kwe-CRP. Kucetyiswa imizuzu eyi-150 yokuzivocavoca ngeveki. Ukuyeka ukutshaya, ukulawula uxinzelelo. Fumana inkxaso nge-e-Health's family therapy.
Imibuzo Ebuzwa Rhoqo
Yintoni iNqanaba le-CRP kwaye Yintoni iMigangatho eQhelekileyo?
I-CRP ephakanyisiweyo kukunyuka kwinqanaba le-C-Reactive Protein egazini kwaye luphawu lokuvuvukala. Amaxabiso aqhelekileyo aphakathi kwe-0-5 mg/L. Amaxabiso aphezulu (ngaphezulu kwe-10 mg / L) abonisa ukusuleleka okanye isifo esingapheliyo. Uvavanyo lwe-hs-CRP luqwalasela <2 mg / L ephantsi kunye> 2 mg / L ephezulu kwingozi yentliziyo. ETurkey, uluhlu lwezalathiso luyahluka ngokuxhomekeke kwilabhoratri; umzekelo, indlela yokuvuvukala ibangelwa yi-cytokines kwaye amaxabiso anokutshintsha kwiiyure ezimbalwa. Qhagamshelana neengcali malunga neziphumo zakho nge-e-Health.
Ziziphi iimpawu ze-CRP ephezulu?
Iimpawu zinokuquka umkhuhlane, ukudinwa, iintlungu zamalungu kunye nokudumba. Iyahluka ngokuxhomekeka kwimeko ephantsi; ukuphelelwa ngumphefumlo kwisifo sentliziyo, ukukhohlela kwintsholongwane. Ukuvuvukala kuchaphazela i-cortisol, kubangela iingxaki zokulala. Yenza iitshekhi zemihla ngemihla zokuxilongwa kwangaphambili; e-Health vavanya iimpawu ngoluvo lwengcaphephe.
Yintoni ebangela i-CRP ephezulu?
Oonobangela lusulelo, isifo samathambo, izifo zentliziyo, umhlaza okanye ukutyeba ngokugqithiseleyo. Ukukhutshwa kwe-Cytokine kukhuthaza isibindi. Izinto ezinobungozi ziquka ukutshaya, uxinzelelo; Utshintsho lokutya lubalulekile kuthintelo.
Ingaba Unyango lwe-CRP ePhezulu luyenzeka?
Ewe, ngokunyanga unobangela (i-antibiotic, anti-inflammatory). Ukutshintsha kwendlela yokuphila, iimvavanyo zokulandelela. Lawula nge-e-Health e-Prescription inkxaso.
lwenziwa njani uvavanyo lwe-CRP kwaye zifumaneka nini iziphumo?
Yenziwa ngesampulu yegazi, iziphumo zilungile kwiintsuku ezi-1-2. Akukho lungiselelo, ixabiso eliphantsi. Ufikelelo nge e-Pulse; Ukulandela umkhondo ngokukhawuleza enkosi kudityaniso.
